SEROPREVALENCE OF INFECTIOUS DISEASES IN BLOOD DONORS BY IDNAT IN A TERTIARY CARE CENTRE IN NORTHERN INDIA

Era's Journal of Medical Research Pub Date : 2020-06-01 DOI:10.24041/ejmr2020.6

S. Warsi, Shafaque Zabin, K. Akhtar, S. Arif

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Abstract

This study was carried out to determine the prevalence of infectious diseases in blood donors by individual donor nucleic acid testing (ID-NAT). Safe blood transfusion practices can save people from being exposed to the risk of transfusion transmittable infections. Serum samples from voluntary and replacement donors were tested for infectious diseases like Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) by ID-NAT and the results were analysed statistically. Majority of the donors were in the 3rd decade of life,15770 (59.6%); followed by in 4th decade of life, 5218 (19.7%).There were 24113(91.1%) males as compared to 2354(8.9%) female donors, with male-female ratio of 29.9:1. Replacement donations were 24583 (92.9%) and voluntary donations were 1884 (7.1%). The seroprevalence of HIV was 19(0.07%), HCV was 173(0.7%), HbsAg was 705(2.6%) and 25570(96.6%) donors were non reactive by ID-NAT. The sensitivity, specificity and diagnostic accuracy by ID-NAT was 99.2%, 96.7% and 99.8% respectively. ID-NAT is a very sensitive testing modality of infectious blood, which decreases the window period of infections, and thus enhances the safety of blood transfusion. Department of Pathology Jawaharlal Nehru Medical College, Faculty of Medicine, A.M.U., Aligarh India. Sumbul Warsi, Shafaque Zabin, Kafil Akhtar, SH Arif ERA’S JOURNAL OF MEDICAL RESEARCH SEROPREVALENCE OF INFECTIOUS DISEASES IN BLOOD DONORS BY IDNAT IN A TERTIARY CARE CENTRE IN NORTHERN INDIA VOL.7 NO.1 Original Article Page: 34 ERA’S JOURNAL OF MEDICAL RESEARCH, VOL.7 NO.1 Contact no: +91-9568467727 Dr. Kafil Akhtar Department of Pathology Jawaharlal Nehru Medical College, Faculty of Medicine, A.M.U., Aligarh India. Email: drkafilakhtar@gmail.com Address for correspondence Received on : xx-xx-xxxx Accepted on : xx-xx-xxxx

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在印度北部的一个三级保健中心，按儿童统计的献血者中传染病的血清流行率

本研究采用个体献血者核酸检测(ID-NAT)确定献血者中感染性疾病的流行情况。安全输血做法可使人们免于面临输血传播感染的风险。通过ID-NAT对自愿和替代献血者的血清样本进行人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)和乙型肝炎病毒(HBV)等传染病检测，并对结果进行统计分析。大多数献血者在生命的第三个十年，15770 (59.6%);其次是40岁，5218人(19.7%)。男性24113例(91.1%)，女性2354例(8.9%)，男女比例为29.9:1。替代捐赠24583例(92.9%)，自愿捐赠1884例(7.1%)。血清HIV阳性率19例(0.07%)，HCV阳性率173例(0.7%)，HbsAg阳性率705例(2.6%)，HbsAg阳性率25570例(96.6%)。ID-NAT的敏感性为99.2%，特异性为96.7%，诊断准确率为99.8%。ID-NAT是一种非常灵敏的感染性血液检测方式，减少了感染的窗口期，提高了输血的安全性。贾瓦哈拉尔·尼赫鲁医学院，印度阿利格尔医科大学医学院。Sumbul Warsi, Shafaque Zabin, Kafil Akhtar, SH Arif ERA 'S医学研究杂志:在印度北部三级医疗中心通过IDNAT的献血者血清传染病的阳性率，第7卷第1期，原文页:34,ERA 'S医学研究杂志，第7卷第1期，联系电话:+91-9568467727，印度阿里加尔。邮箱:drkafilakhtar@gmail.com接收地址:xx-xx-xxxx接收地址:xx-xx-xxxx

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Era's Journal of Medical Research

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