Nanotechnology Based Drug Delivery for HIV-AIDS Treatment

I. Sailaja, Manoj Baghel, I. A. Shaker
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引用次数: 1

Abstract

One of the biggest challenges of the world in this 21st century is to cure HIV-AIDS. In Present scenario different antiviral drugs are available in the market to reduce the worse condition and manage improved survival rate. These drugs are manageable but their bioavailability, lower permeability and poor half life of the drugs have limitations. If the drug is preferred in higher dosage in AIDS patients, the drug leads to toxicity and adverse effects to patients and increase resistant against HIV & if the drug is preferred in lower dose along with nano carriers it will reach the target area for beneficial effect, therefore drugs Lacking of Knowledge in Potent Drug delivery systems is due to instability, chemical degradation and tissue barrier difficulties are reasons to reach drug target successfully. In this scenario Nanotechnology based antiretroviral drugs delivery holds drug and will provide to cure AIDS. Nanotechnology based deliver system Nanocarriers like Liposomes, dendrimers, Nanoparticles, Polymeric Micelles, Nanovesicles, Nanoemulsion provide the way to deliver drug to targeting tissue. Nanobased carriers revolutionized the field of Pharmaceutics and Pharmaco Kinetic’s in target drug delivery. The present study depicts nano based ARV drug provides increase efficiency with less adverse effects to control HIV. Like same way we can provide and increase nanobased drug delivery capacity to other available HIV drugs.
基于纳米技术的HIV-AIDS药物递送治疗
21世纪世界面临的最大挑战之一是治愈艾滋病毒和艾滋病。在目前的情况下,市场上有不同的抗病毒药物,以减少病情恶化,提高生存率。这些药物是可控的,但它们的生物利用度、渗透性低和半衰期差都有局限性。如果在艾滋病患者中首选高剂量的药物,会对患者产生毒性和不良反应,增加对HIV的耐药性;如果首选低剂量的药物,伴随着纳米载体,会到达靶点区域,从而产生有益的效果,因此药物缺乏有效药物传递系统的知识,因为药物不稳定,化学降解和组织屏障困难是成功到达药物靶点的原因。在这种情况下,以纳米技术为基础的抗逆转录病毒药物递送将保留药物并提供治疗艾滋病的方法。纳米载体如脂质体、树状大分子、纳米颗粒、聚合物胶束、纳米囊泡、纳米乳液等提供了将药物输送到目标组织的途径。纳米载体彻底改变了药剂学和药物动力学领域的靶向药物递送。本研究描述了纳米基抗逆转录病毒药物在控制艾滋病毒方面具有更高的效率和更小的副作用。以同样的方式,我们可以为其他可用的HIV药物提供并提高纳米药物的输送能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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