Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Mean Platelet Volume in Behçet Disease Patients with and without Ocular Involvement

Abstract

Objective: To evaluate the relationship between neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet/lymphocyte ratio (PLR) and risk of ocular involvement in Behçet Disease (BD). Material and Methods: This prospective randomised study included 45 patients with ocular BD (Group1), and 86 patients with BD without ocular involvement (Group2) and 90 control subjects. The NLR, MPV, PLR and other laboratory tests were evaluated in the groups. Results: A significant difference was found in NLR and PLR values between patients with BD (n=131) and control subjects (n=90) (p<0.001). No statistically significant difference in laboratory parameters was found in BD group without ocular involvement when compared with ocular BD group, except MPV level. There was a positive correlation between MPV and activation of ocular BD (p<0.001). In the receiver-operating characteristic analysis, MPV cut off point was 8.80 and predicted the presence of active ocular BD with 66.7% sensitivity and 60.4% specificity. HLA-B51 positivity is higher in patients with ocular BD than BD without ocular involvement (p<0.001). Conclusion: Our results show that increased NLR and PLR levels may predict BD. Although NLR, and PLR are higher in BD patients, no differences were found when comparing patients with and without ocular involvement. The MPV may be a simple, inexpensive, and convenient diagnostic marker of active ocular BD.