EFEITO DA PUNICA GRANATUM (ROMÃ) EM PROCESSOS INFLAMATÓRIOS INDUZIDOS EM RATOS E SUAS IMPLICAÇÕES NO EIXO HIPOTÁLAMO-HIPÓFISE-ADRENAL

Abstract

After tissular injury initiate the cicatrization events: inflammation, proliferation and reshuffle. The research had as objectives evaluate the herbal remedy effects of pomegranate on wounds and it’s implications in neuroendocrine pathways of stress. Protocolo CEUA 02/2017. Induced wounds on anesthetized rats backs. Treated for 3 days with saline or pomegranate (tea and/or pulp). At the end of fourth day, was inoculated Evans blue (EB, 0,3 mL 2,5%) by hepatic vein in all rats. One half of the lesions, after 24 hours, had read the EB at 640 nm wave-length and the other half was weighted at 60° C, diference expressed as exudate. The adrenals participate at the content determination of ascorbic avid (AAA), readings at 520 nem. ANOVA-Turkey significance of 5%. Found a significant increased of AAA, adrenals weight and permeability to AE decreased at those treated with pomegranate compared to the group with saline (F = 5,8; P = 0,005; F = 5,9; P < 0,01; F = 9,8; P = 0,0011) what suggests the pomegranate anti-inflammatory action and adaptogenic property, although the exudate medium content had been equal in all treatment conditions (F = 2,7; P = 0,0677).