Cryotherapy Effect in Prevention of Oral Mucositis in Adult Patients who Received Chemotherapy : An Evidence-Based Review

Saba Bashtawi
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Abstract

Prevention and management of oral mucositis (OM) in adult patients who received chemotherapy are challenging issues for health care professionals. Numerous methods have been tested to cope with this problem. Aims: the goal of this evidencebased review is to identify effectiveness of cryotherapy in prevention of oral mucositis in adult patients who received chemotherapy. The method: a literature search was performed using an appropriate keywords search in Cochrane, Science Direct and Pubmed databases from 2009 to 2013. However, two exclusive studies that were conducted in 2007 have been included. Nine full papers are included in this review. The inclusion criteria were : adult cancer patients who had OM, Oral mucositis induced by chemotherapy, using cryotherapy to prevent OM and articles written in English language. The findings: cryotherapy has an effective method in prevention of OM with chemotherapy regimens that include 5FU regimens and high dose melphalan. Conclusions: cryotherapy is an effective method for prevention of oral mucositis in patients who received two specific chemotherapy regimens that include 5FU regimens and high dose melphalan. In addition, the efficacy of oral cryotherapy is affected by the types of chemotherapy regimens including the half life for each one and it depends on the causative mechanisms of oral mucositis including direct and indirect mucositis. Recommendations: researchers recommended doing additional studies (clinical trials) to broaden the potential applications of cryotherapy in clinical settings, with increased sample size in order to generalize findings, and to increase nursing awareness with this method.
冷冻疗法在预防成年化疗患者口腔黏膜炎中的作用:一项基于证据的综述
在接受化疗的成人患者中预防和管理口腔黏膜炎(OM)是卫生保健专业人员面临的具有挑战性的问题。为了解决这个问题,已经试验了许多方法。目的:本循证综述的目的是确定冷冻治疗在预防接受化疗的成年患者口腔黏膜炎中的有效性。方法:选取2009 - 2013年Cochrane、Science Direct和Pubmed数据库中合适的关键词进行文献检索。然而,2007年进行的两项独家研究被纳入其中。本综述收录了九篇全文。纳入标准为:患有OM的成年癌症患者、化疗引起的口腔黏膜炎、使用冷冻疗法预防OM以及以英文撰写的文章。研究结果表明:冷冻治疗在包括5FU方案和大剂量美伐兰在内的化疗方案中具有有效的预防OM的方法。结论:冷冻治疗是预防接受5FU方案和大剂量美法兰两种特异性化疗方案患者口腔黏膜炎的有效方法。此外,口腔冷冻治疗的疗效受化疗方案的类型(包括每种化疗方案的半衰期)和口腔黏膜炎的致病机制(包括直接和间接粘膜炎)的影响。建议:研究人员建议进行更多的研究(临床试验),以扩大冷冻疗法在临床环境中的潜在应用,增加样本量,以推广研究结果,并提高护理人员对这种方法的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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