A retrospective study of the Antibiotics Prophylactic Use in Appendectomy Patient with ATC/DDD and DU 90% Method in Regional General Hospital in Jakarta

Abstract

Appendicitis is the most common cause of acute abdomen which requires surgical treatment to prevent worse complications. Inappropriate use of prophylactic antibiotic is one of the triggers surgical site infection. This retrospective study aimed to determine the quantitative analysis of antibiotics prophylactic use according to the anatomical therapeutics chemical classification/defined daily dose (ATCC/DDD) methodology. This research was conducted using cross sectional design with retrospective data collection during January to December 2016 at regional general hospital in Jakarta and data were analyzed using the DDD method and drug utilization (DU) 90%. A total of 119 total patients included as samples in this study. The results showed that the ceftriaxone was prophylactic antibiotic with highest DDD was 46.52 /100 patient-days. Prophylactic antibiotics included in DU 90% segment were ceftriaxone and metronidazole. These study underline the need for antibiotic stewardship to improve the quality of antibiotic use.