Cell-mediated cytotoxicity (phenotypes of cd8 and cd16) in immune response (Review)

Abstract

The immune system is a complex human mechanism that performs a wide range of effector functions, as well as powerful and not yet well-understood regulatory processes are involved in its activities. Phagocytosis is one of the oldest defense mechanisms (paleoimmunity). More evolutionarily young is the mechanism of cellular immunity (neoimmunity). T-lymphocytes mature in the thymus and are divided into: T-suppressors, T-killers, T-helpers and differ in function and surface antigens. Domestic and foreign authors indicate that evolutionarily young Ts cells play a large role in regulating the response, both cellular and humoral immunity. In a number of sources, the authors indicate that northerners of different age and socio-professional groups have an increased level of immunosuppression. The literature over the past 30 years has shown that in extreme conditions, an increase in the concentrations of CD8 +, CD16 + cells is necessary in the formation of an adaptive immune response