Findings from multifocal electroretinography of posterior uveitis in Behcet's disease

Chinese Ophthalmic Research Pub Date : 2010-03-10 DOI:10.3969/J.ISSN.1003-0808.2010.03.018

Luo Guangwei, Wen Feng, Jiang Fu-tian, H. Shi-zhou, Long Shixian, Liu Cai-jiao, Guan Tian-qin

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Abstract

Background Behcet's disease is a refractory panuveitis with high blindness rate.Multifocal electroretinography (mfERG) is a useful tool for the evaluation of the function of the posterior retina.ObjectiveThe aim of this study is to assess the characteristics of Behcet's disease using the mfERG.Methods mfERG was recorded in 68 eyes of 39 cases with active stage of Behcet's disease.All of the patients were diagnosed based on the Standard of International Study Group for Behcet's Disease and assigned to the cystoid macular edema (CME) group and the diffuse macular edema (DME) group after assessment by fundus fluorescein angiography (FFA).Seventeen normal subjects were used as controls.Oral informed consent was obtained from all of the subjects prior to this trial.mfERG recording followed the ISCEV Guidelines for Clinical Multifocal Electroretinography (2007 edition).The response density and latency of P1 and N1 waves in 6 rings were analyzed and compared.Results The amplitudes of N_1 waves from rings 1 through 6 and N1 wave from rings 1 through 5 were significantly declined in patients with Behcet's disease compared with normal control (P＜0.01).All of the latencies of P_1 waves from rings 1 through 6 were insignificantly shortened in patients with Behcet's disease compared with normal control (P＞0.05).The amplitudes of P_1 and N_1 waves from rings 1 through 6 in diffuse macular edema group were considerably lower than those in the cystoid macular edema group (P＜0.05,P＜0.01).A test of visual acuity showed a negative correlation to the amplitude and latency of N_1 wave (r=-0.36,-0.37,P＜0.05 ) and a positive correlation with the amplitude of N1 wave (r=0.43,P＜0.05) in the DME group.In the CME group,a test of visual acuity presented a negative correlation to the amplitude and latency of N1 wave and latency of P1 (r=-0.41,-0.35,-0.40,P＜0.05 ) and a positive correlation with the amplitude of P1 wave (r=0.48,P＜0.05).Conclusion mfEGR demonstrates that retinal electro-activity is abnormal in eyes with Behcet's disease.The distinct functional disorder is situated around the fovea. Key words: Behcet's disease; uveitis; multifocal electroretinography

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白塞病后葡萄膜炎的多灶视网膜电图表现

背景白塞病是一种致盲率高的难治性全葡萄膜炎。多焦视网膜电图(mfERG)是评估后视网膜功能的有用工具。目的应用mfERG评价白塞病的特征。方法对39例白塞病活动期68眼进行mfERG记录。所有患者均按照白塞病国际研究组标准进行诊断，经眼底荧光素血管造影(FFA)评估后分为囊状黄斑水肿(CME)组和弥漫性黄斑水肿(DME)组。17名正常受试者作为对照。在本次试验之前获得了所有受试者的口头知情同意。mfERG记录遵循ISCEV临床多焦点视网膜电图指南(2007年版)。分析比较了6个环中P1波和N1波的响应密度和潜伏期。结果与正常对照组相比，白塞病患者1 ~ 6环N_1波和1 ~ 5环N1波振幅明显降低(P<0.01)。与正常对照组相比，白塞病患者1 ~ 6环P_1波潜伏期均无显著缩短(P < 0.05)。弥漫性黄斑水肿组1 ~ 6环P_1、N_1波幅均显著低于囊状黄斑水肿组(P<0.05,P<0.01)。DME组视敏度与N_1波振幅和潜伏期呈负相关(r=-0.36，-0.37,P<0.05)，与N1波振幅呈正相关(r=0.43,P<0.05)。CME组视力与N1波振幅、潜伏期、P1波潜伏期呈负相关(r=-0.41、-0.35、-0.40,P<0.05)，与P1波振幅呈正相关(r=0.48,P<0.05)。结论mfEGR显示白塞病患者视网膜电活动异常。明显的功能障碍位于中央凹周围。关键词:白塞病;葡萄膜炎;多病灶的electroretinography

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Chinese Ophthalmic Research

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