Phytochemical and Pharmacology Effect of Calotropis gigantea as Anti-Cancer Therapy: Systematic Review

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2021-12-05 DOI:10.18860/planar.v1i0.1458

R. Mutiah, Humaira Ramzi, Jesi Aulia Bustami

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引用次数: 1

Abstract

The high prevalence of cancer in the world makes many researchers look for alternative therapies that can be used to treat cancer. One of them is by using traditional plants, namely Calotropis gigantea R.Br. This is due to alkaloids, glycosides, and tannins in plants that function as anticancer. The purpose of this study was to dig deeper into information related to the phytochemistry and pharmacology effect of Calotropis gigantea as an anticancer therapy and can be used as a reference for the development of traditional medicines. The method used is PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses), with inclusion and exclusion criteria, 11 articles were selected for review. The results showed that Calotropis Gigantea contains Calotropin, Calotroposide A, oxypregnane oligoglycoside compounds, which inhibit cancer cell growth through the mechanism of apoptosis induction and ROS inhibition. From this systematic review, it can be recommended that the plant Calotropis gigantea can be further developed into standardized herbal medicine and phytopharmaceuticals.

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巨茶甘油三酯抗癌的植物化学和药理作用:系统综述

世界上癌症的高发病率使得许多研究人员寻找可用于治疗癌症的替代疗法。其中一种是利用传统植物，即卡罗通斯·吉安特茶。这是由于植物中的生物碱、糖苷和单宁具有抗癌作用。本研究旨在深入挖掘巨茶甘露的植物化学和药理抗癌作用的相关信息，为中药开发提供参考。采用PRISMA (Preferred Reporting Items for Systematic Reviews and meta - analysis)方法，按照纳入和排除标准，共选择11篇文章进行综述。结果表明，巨茶卡罗tropis含有卡罗tropin、卡罗troposide A、氧孕烷寡糖苷类化合物，通过诱导凋亡和抑制ROS的机制抑制癌细胞生长。通过对该植物的系统评价，建议将巨角甘露进一步开发为标准化的中草药和植物药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)

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