Clinical spectrum and resistance pattern of community-acquired invasive Staphylococcus aureus infection in children

Abstract

Introduction: The incidence of Staphylococcal infections has been increasing over the last 20 years and MRSA infection is becoming an important cause of hospital infection among children. Aims and Objectives: The study aimed to delineate the clinical spectrum of Staphylococcus aureus infection in children, their complications, antimicrobial resistance patterns and response to treatment. Materials and Methods: Children with suspected community acquired invasive S. aureus infections were retrospectively identified. Fifty patients with proven S.aureus infection on culture from clinically relevant sites were included. Their symptoms, course of disease, complications, antimicrobial resistance pattern and response to treatment is described. Results and Conclusions: Out of a total of 50 cases, S.aureus isolates from 31 (62%) cases were sensitive to oxacillin while resistance to this antibiotic was reported in 19 (38%) cases. Most common site for localisation of infection was present in lungs (40%) followed by CNS (16%), skin (8%) and bone (4%) The focality of infection and pattern of resistance were not significantly associated with outcomes.