To Determine Pivotal Genes Driven by Methylated DNA in Obstructive Sleep Apnea Hypopnea Syndrome

Comput. Math. Methods Medicine Pub Date : 1900-01-01 DOI:10.1155/2021/5520325

Yan Li, Yajuan Zhang

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引用次数: 1

Abstract

Obstructive sleep apnea syndrome (OSAHS) is a widespread respiratory dysfunction that has attracted more and more attention in recent years. Recently, a large number of studies have shown that abnormal DNA methylation epigenetically silences genes necessary for the pathogenesis of human diseases. However, the exact mechanism of abnormal DNA methylation in OSAHS is still elusive. In this study, we downloaded the OSAHS data from the GEO database. Our data for the first time revealed 520 hypermethylated genes and 889 hypomethylated genes in OSAHS. Bioinformatics analysis revealed that these abnormal methylated genes exhibited an association with the regulation of angiogenesis, apoptosis, Wnt, and ERBB2 signaling pathways. PPI network analysis displayed the interactions among these genes and validated several hub genes, such as GPSM2, CCR8, TAS2R20, TAS2R4, and TAS2R5, which were related to regulating liganded Gi-activating GPCR and the transition of mitotic metaphase/anaphase. In conclusion, our study offers a new hint of understanding the molecular mechanisms in OSAHS progression and will provide OSAHS with newly generated innovative biomarkers.

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确定阻塞性睡眠呼吸暂停低通气综合征中甲基化DNA驱动的关键基因

阻塞性睡眠呼吸暂停综合征(OSAHS)是近年来越来越受到重视的一种广泛存在的呼吸功能障碍。近年来，大量研究表明，异常的DNA甲基化在表观遗传上使人类疾病发病所必需的基因沉默。然而，OSAHS中异常DNA甲基化的确切机制尚不清楚。在本研究中，我们从GEO数据库中下载OSAHS数据。我们的数据首次揭示了OSAHS中520个高甲基化基因和889个低甲基化基因。生物信息学分析显示，这些异常甲基化基因与血管生成、细胞凋亡、Wnt和ERBB2信号通路的调控有关。PPI网络分析显示了这些基因之间的相互作用，并验证了GPSM2、CCR8、TAS2R20、TAS2R4和TAS2R5等中心基因，这些中心基因与调节配体gi激活GPCR和有丝分裂中期/后期转变有关。总之，本研究为了解OSAHS进展的分子机制提供了新的线索，并将为OSAHS提供新的创新生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comput. Math. Methods Medicine

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