Study of the Antihypertensive Peptides Derived from Alpha-Lactalbumin Hydrolysate after Simulation of Digestion

Abstract

Oxidative stress and free radical generation have been linked to a multitude of Noncommunicable Chronic Diseases (NCDs) 1 . Dietary antioxidants can help the body reduce oxidative stress 2 . Protein hydrolysates, sources of bioactive peptides, are widely used in food technology for their nutritional and functional properties (antioxidant, antihypertensive, etc) that depend on their physicochemical and structural characteristics 4,5 . The aim of this work was to correlate the antihypertensive activity found in vitro with in silico studies and to evaluate possible structure-activity relationships and possible mechanisms of antihypertensive capacity of the obtained peptides.