Detection of extension and distribution diversity of coronary artery diseases by gender using Syntax score I

Abstract

Background: Although the extension and distribution of coronary artery diseases by gender was found in a same pattern, some studies reported controversial results, so we aimed to investigate these differences. Materials and Methods: Our study included a total of 963 patients with 67% of men and 33% of women. Results: Baseline features were similar except diabetes mellitus and age which were higher in women (P = 0,004 and P < 0,001, respectively). There was a significant difference between groups (P = 0.031). Women had significantly more one-vessel left anterior descending (LAD) lesions (30.8% vs. 22.0%; P = 0.004). However, there were no differences for other locations (P > 0.05). When collecting all kind of lesions in a same cluster (including one-, two-, and three-vessel diseases totally), the left circumflex artery (LCx) cluster was found significantly more in men (55.7% vs. 48.7%, P = 0.043). There was no difference in segmental distribution of lesions (P = 0.473). Low Syntax score was found to be the best determinant for one-vessel LAD lesions (P < 0.001); in contrast, intermediary and high Syntax scores were found for LCx cluster (P < 0.001). Syntax score I was found to be a significant negative predictor for one-vessel LAD lesions (P < 0.001, OR: 0.857), and low-density lipoprotein (LDL) cholesterol and Syntax score I and HbA1c were significant positive predictors for LCx cluster (P = 0.011, odds ratio [OR]: 1.011; P < 0.001, OR : 1,10; P = 0,015, OR: 1,22, respectively). Conclusions: We found one-vessel LAD lesions to be significantly more in women and LCx cluster in men. Syntax score I was found to be a negative predictor for one-vessel LAD lesions, but Syntax score I, LDL cholesterol, and HbA1c were positive predictors for LCx cluster.