The Effect of Aerobic Training with Vitamin C Supplementation on Myeloperoxidase, Asymmetric Dimethyl Arginine and Blood Pressure in Middle-Age Hypertensive Overweight Men

Ailin Alishahi, K. Azizbeigi, K. Salamat, M. Yektayar
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引用次数: 3

Abstract

Background: Cardiovascular diseases such as hypertension are global health concerns. Objectives: The purpose of this study was the effect of intensive aerobic training with vitamin C supplementation on myeloperoxidase (MPO), asymmetric dimethyl arginine (ADMA), and blood pressure (BP) in hypertensive men. Methods: Fortyhypertensivemen(age: 44.6 ± 3.5y,bodymassindex: 28.2 ± 1.2kg.m -2 )volunteeredtoparticipateinthisstudyand wererandomlydividedintofourgroupsof aerobictrainingwithvitaminC(ATV;N=10),aerobictrainingwithplacebo(ATP;N=10), vitamin C group (VC; N = 10) and control (Con; N = 10). The exercise training consisted of running training, which was done three timesaweekfor10weeks,withtheintensityof 75% -85% HRmax,andthedurationof 20-45minutes. ATPandVCgroupsconsumed daily500mgof vitaminCorplacebo. Fastingbloodsamplesweremeasuredbeforethestarttrainingprotocoland24hourafterlast training sessions to measure MPO and ADMA in the serum. Results: TheresultsofpresentstudyshowedthatADMAandBPweresignificantlydecreasedonlyinATVandATP(P ≤ 0.05). However, MPO did not change significantly (P > 0.05). Also, were seen that no significant difference between ATV and ATP groups (P > 0.05). Conclusions: It can be concluded that, aerobic training caused to decrease of dimethyl arginine, that can be a good strategy for control or decrease of blood pressure in hypertensive subjects, however intensive aerobic training with vitamin C may have better efficacy.
补充维生素C有氧训练对中年高血压超重男性髓过氧化物酶、非对称二甲基精氨酸和血压的影响
背景:高血压等心血管疾病是全球关注的健康问题。目的:本研究的目的是强化有氧训练和补充维生素C对高血压男性髓过氧化物酶(MPO)、不对称二甲基精氨酸(ADMA)和血压(BP)的影响。方法:40例高血压患者(年龄44.6±3.5y,体质指数28.2±1.2kg)。(2)名志愿者参加了这项研究,并被随机分为四组:维生素C有氧训练组(ATV, N=10)、安慰剂有氧训练组(ATP, N=10)、维生素C组(VC;N = 10)和对照组(Con;N = 10)。运动训练包括跑步训练,每周三次,持续10周,强度为75% -85% HRmax,持续时间为20-45分钟。两组每天摄入500毫克维生素c。在开始训练方案前和最后一次训练后24小时测量空腹血样,以测量血清中的MPO和ADMA。结果:本研究结果显示,admav和bpv仅在atvandatp中显著降低(P≤0.05)。MPO无显著变化(P > 0.05)。ATV组与ATP组间无显著差异(P > 0.05)。结论:有氧训练导致二甲基精氨酸降低,是控制或降低高血压患者血压的良好策略,但强化有氧训练加维生素C可能效果更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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