Analogue of glucagon-like peptide-1 - properties, mechanisms of action, prospects for use

Abstract

Glucagon-like peptide-1 is an isulin-like peptide hormone from the incretin family. It is secreted by L-cells of the mucous membrane of the ileum and colon, enhances insulin secretion and is a physiological regulator of appetite. The most popular pharmaceutical analogue of GLP-1 at the moment is liraglutide. Liraglutide also activates GLP-1 receptors, but is more stable and allows you to get a more powerful effect due to the prolongation of the drug. It is known that the action of liraglutide extends to all tissues with GLP-1 receptors, but now the drug is used only for correction of body weight and in the complex therapy of patients with type 2 diabetes mellitus. Thus, we have a drug with numerous and multidirectional effects, the full range of possibilities of which has not yet been explored. In this article, we analyze the possibilities of alternative use of this drug, based on literature data.