Optimization of Nanoemulsion in Chemix 7.00 Program : Using Isopropyl Myristate as Oil Phase

Abstract

. This research is the development of nanoemulsion base preparation by applying a ternary diagram system using Chemix 7.00. This study aims to see the advantages of the Chemix 7.00 series program in determining the focus area for nanoemulsion in a mixture of oil phase (Isopropyl Myristate), smix (tween 80 and propylene glycol), and water at various ratios from 1 to 9 and 9 to 1 part. This research applies the high energy method with Ultra Turrax High Share Homogenization (HSH) at a speed of 20,000 rpm 15 minutes to form a nanoemulsion. All formulas were evaluated with the Chemix 7.00 program to see which formulas form a stable nanoemulsion area according to the standard criteria for nanoemulsion preparations in general. The result was 45 nanoemulsion bases were obtained. The use of the Chemix 7.00 ternary diagram yields 14 bases forming a nanoemulsion area with an average particle size of below 500 nm. Among the 14 formulas, there is 1 formula bases that are stable and meets the standard of nanoemulsion research, namely the nanoemulsion base with a ratio of 4.45.50 (oil, smix, water) with a particle size of 185.7 nm each, zeta - 28.2, PDI 0,2 mV, D90 measuring 120 nm and the TEM morphology is quite round. Determination of the nanoemulsion base area using the Chemix series 7.00 program is quite helpful in data processing so that optimal research results are obtained.