Epigenetic Drugs - The Future of Cancer Therapy

Abstract

Epigenetics refers to any alteration in gene expression that occurs without affecting the underlying DNA sequence. Epigenetic mechanisms regulate the accessibility of chromatin to transcription factors by promoting nucleosomal rearrangement via the addition or removal of acetyl or/and methyl groups to histones. Nucleosomes are basic units of chromosomes comprising of 147 base pairs of DNA wrapped around an octamer of histone proteins