[Kidney cell damage and liberation of enzymes].

Abstract

The pathophysiological and pathobiochemical background of enzymuria in patients with renal involvement in discussed. Selected markers of the human nephron such as angiotensinase-A, aminopeptidase-M, L-gamma-glutamyl-transferase and dipeptidylpeptidase-IV are characterized; inductive as well as ischaemic/toxic events may induce increased shedding of membrane bound marker-enzymes. Pathological enzyme excretion profiles related to defined renal diseases indicate that tissue-proteinuria of renal origin is a potential noninvasive tool for diagnostic purposes.