Topical NSAIDs in Prevention of Postcataract Macular Edema

Ahmed A Alnagdy, A. M. Eissa, Amr M. El-Kannishy
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Abstract

Postoperative macular edema is considered one cause of diminished vision after cataract surgery. It was approved that inflammatory mediators especially prostaglandins play a key role in macular edema formation especially in the presence of risk factors that affect blood-retinal barrier such as diabetes, uveitis, tear of posterior capsule, and vitreous loss. So, anti-inflammatory medications like corticosteroids and NSAIDs are the cornerstone of macular edema managements. In spite of using corticosteroids as gold standard for treatment of ocular inflammation, they cannot be used for prolonged period due to associated adverse effects. Lastly, there were many studies about benefits of NSAIDs in management and prevention of macular edema to avoid the side effects of corticosteroids.
局部非甾体抗炎药预防白内障后黄斑水肿
术后黄斑水肿被认为是白内障术后视力下降的原因之一。炎症介质尤其是前列腺素在黄斑水肿形成中起关键作用,特别是在糖尿病、葡萄膜炎、后囊撕裂、玻璃体丢失等影响血视网膜屏障的危险因素存在的情况下。因此,像皮质类固醇和非甾体抗炎药这样的抗炎药物是黄斑水肿治疗的基础。尽管使用皮质类固醇作为治疗眼部炎症的金标准,但由于相关的不良反应,它们不能长期使用。最后,关于非甾体抗炎药在管理和预防黄斑水肿方面的益处,以避免皮质类固醇的副作用,有很多研究。
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