SELECCIÓN CONTRA DISPLASIA DE CADERA CANINA EN EL OVEJERO ALEMÁN

M. Poverene
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Abstract

Canine hip dysplasia (CHD) is a progressive and disabling disorder in large dog breeds, such as the German Shepherd dog. Breeding sires and dams free of dysplasia is the only way to reduce its incidence. Several diagnostic methods have been developed based on radiographic examination, on the basis of which dogs are selected for breeding. CHD has a polygenic hereditary basis and environmental influence, with a median to low heritability (ca. 0,20 to 0,40), so the progress in phenotypic selection has been slow. In Argentina, the prevalence of dysplasia in German Shepherd dogs remains high (> 25%) and it is impossible to predict its incidence in the offspring of the breeding stock. Some countries have implemented a selection based on the estimated breeding value, obtaining an important advance. Genome-wide association studies have revealed numerous CHD-associated markers and several candidate genes have been found that point to the possibility of implementing genomic selection in the near future. Key words: canine hip dysplasia, German Shepherd dog, phenotypic selection, genomic selection, estimated breeding value
德国牧羊犬对犬髋关节发育不良的选择
犬髋发育不良(CHD)是一种进行性和致残性疾病,发生在大型犬种,如德国牧羊犬。繁殖没有发育不良的幼崽和幼崽是降低发病率的唯一途径。基于放射检查已经开发了几种诊断方法,在此基础上选择狗进行繁殖。冠心病具有多基因遗传基础和环境影响,遗传率中值至低(约0.20 ~ 0.40),因此在表型选择方面进展缓慢。在阿根廷,德国牧羊犬的发育不良患病率仍然很高(约25%),无法预测其在种畜后代中的发病率。一些国家已经实施了基于估计育种价值的选择,取得了重要进展。全基因组关联研究揭示了许多与冠心病相关的标记和几个候选基因,这些基因表明在不久的将来可能会实施基因组选择。关键词:犬髋发育不良,德国牧羊犬,表型选择,基因组选择,估计育种价值
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