Biological Evaluation of Aminoindane Derivatives as Antibacterial Agents

Abstract

The aminoindane ring is the most studied skeletal structure in synthetic chemistry, in the synthesis of intermediates and because it is a biologically active molecule. Bioactive properties of the aminoindane ring include antibacterial, antiviral, antiapoptotic, antipyretic, analgesic, anticonvulsant, and antiparkinsonian activities. The most important bacteria in responsibility of nosocomial infections obtained in hospitals across the world are Acinetobacter baumannii and Methicillin-resistant Staphylococcus aureus. MRSA and A. baumannii have become resistant to numerous antibiotics. The development of novel antibiotic drugs is thus urgently needed. This study as investigated at the antibacterial effects of previously synthsized compounds 8 and 9 on A. baumannii and MRSA disease microorganisms. Studies on antibacterial activity employed disc diffusion and microdilution techniques. The investigation revealed that whereas the pathogenic organisms of compounds 8 and 9 formed zones that inhibited bacterial development, no zones formed in compounds 5, 6, and 7. Compounds 8 and 9's zone diameters against A. baumannii and MRSA were estimated to be between 0.7 and 1.0 mm. The range of MIC values was 3.9025–15.625 µg/ml. These results was envisaged the conclusion that derivatives with an aminoindane ring may function as MRSA and A. baumannii antibacterial agents.