The Effect of Triponyl Sulphate on Fetuses Development and Placental Abnormalities in Inducing Preeclampsia of Rattus norvegicus animal model

W. Purwatiningsih, D. E. Aryani, D. Vidiastuti, Y. Oktanella, A. Firmawati
{"title":"The Effect of Triponyl Sulphate on Fetuses Development and Placental Abnormalities in Inducing Preeclampsia of Rattus norvegicus animal model","authors":"W. Purwatiningsih, D. E. Aryani, D. Vidiastuti, Y. Oktanella, A. Firmawati","doi":"10.21776/UB.VETBIOCLINJ.2019.001.01.6","DOIUrl":null,"url":null,"abstract":"Preeclampsia is one of the obstetrical problems that can cause maternal and fetal morbidity and mortality. Preeclampsia causes the fetus born prematurely and low fetal weight. This is caused by high blood pressure which causes decrease of blood delivery to the placenta, so the supply of oxygen and food to the fetus decreases. As a result, fetal development inhibits and trigger born prematurely. More fatal, this disease cause the release of placental tissue from the uterus prematurely. The aim of this study was to determine the effect of administration of triponyl sulfate as induction of increased blood pressure in preeclampsia animal models, fetal development with alizarin red staining and placental abnormalities. The experimental animals were rats Rattus norvegicus mated with male rats monomating , 4 months old and 250-300 grams body weigh. Pregnant female rats were induced by triponyl sulfate 70 mg / kg BW (k +) and without induced by triponyl sulfate (k-). The results of the study showed that there were formation of the sternal bone in k- and malformation of the sternum bone at k +. Placental abnormalities occured in k +, it could be seen in the presence of ghos villi in blood vessel abnormalities in the preeclampsia placenta caused by there was no invation of trophoblast cells in the whole or partial spiral arteries and the mean of blood pressure increased.","PeriodicalId":432813,"journal":{"name":"Veterinary Biomedical and Clinical Journal","volume":"62-63 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Biomedical and Clinical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21776/UB.VETBIOCLINJ.2019.001.01.6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Preeclampsia is one of the obstetrical problems that can cause maternal and fetal morbidity and mortality. Preeclampsia causes the fetus born prematurely and low fetal weight. This is caused by high blood pressure which causes decrease of blood delivery to the placenta, so the supply of oxygen and food to the fetus decreases. As a result, fetal development inhibits and trigger born prematurely. More fatal, this disease cause the release of placental tissue from the uterus prematurely. The aim of this study was to determine the effect of administration of triponyl sulfate as induction of increased blood pressure in preeclampsia animal models, fetal development with alizarin red staining and placental abnormalities. The experimental animals were rats Rattus norvegicus mated with male rats monomating , 4 months old and 250-300 grams body weigh. Pregnant female rats were induced by triponyl sulfate 70 mg / kg BW (k +) and without induced by triponyl sulfate (k-). The results of the study showed that there were formation of the sternal bone in k- and malformation of the sternum bone at k +. Placental abnormalities occured in k +, it could be seen in the presence of ghos villi in blood vessel abnormalities in the preeclampsia placenta caused by there was no invation of trophoblast cells in the whole or partial spiral arteries and the mean of blood pressure increased.
硫酸三苯酯对诱导褐家鼠子痫前期胎儿发育及胎盘异常的影响
先兆子痫是一个产科问题,可导致产妇和胎儿的发病率和死亡率。子痫前期会导致胎儿早产和胎儿体重过低。这是由高血压引起的,高血压会导致输送到胎盘的血液减少,因此胎儿的氧气和食物供应减少。因此,胎儿发育受到抑制并引发早产。更致命的是,这种疾病会导致胎盘组织过早地从子宫中释放出来。本研究的目的是确定三聚硫酸酯在诱导子痫前期动物模型血压升高、茜素红染色胎儿发育和胎盘异常中的作用。实验动物为褐家鼠与雄性交配的单龄大鼠,4月龄,体重250 ~ 300 g。用70 mg / kg BW (k +)硫酸三聚酯诱导妊娠雌性大鼠,用k-诱导妊娠雌性大鼠。研究结果表明,k-时胸骨形成,k +时胸骨畸形。胎盘异常发生于k +,可见子痫前期胎盘血管中存在高绒毛,其原因是全或部分螺旋动脉未见滋养细胞浸润,血压平均值升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信