Monte Carlo simulation of diabetic macular edema changes on optical coherence tomography data

A. Correia, L. Pinto, A. Araújo, S. Barbeiro, F. Caramelo, Paulo Menezes, A. M. Morgado, P. Serranho, Rui Bernardes
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引用次数: 8

Abstract

Optical coherence tomography (OCT) scans were acquired from healthy controls and patients with diabetic macular edema (DME), a common complication of diabetes characterized by increased retinal thickness due to fluid accumulation. The collected OCT data was divided into three distinct groups: healthy subjects, DME patients with significantly increased outer nuclear layer (ONL) thickness and DME patients without visible changes in the ONL. For each group, the ONL was segmented and processed, yielding a representative A-scan. Using reference values for the physical and optical characteristics of the healthy human retina, we used a Monte Carlo method with a model for the ONL to simulate an A-scan for each group and compare it to the real OCT data. This allowed to identify which alterations in the cellular characteristics are responsible for the changes observed in the OCT scans of the diseased groups.
蒙特卡罗模拟糖尿病黄斑水肿在光学相干断层成像数据上的变化
光学相干断层扫描(OCT)从健康对照和糖尿病性黄斑水肿(DME)患者中获得,DME是糖尿病的常见并发症,其特征是由于液体积聚导致视网膜厚度增加。将收集到的OCT数据分为三组:健康受试者、外核层(ONL)厚度明显增加的DME患者和ONL无明显变化的DME患者。对于每一组,ONL被分割和处理,产生一个代表性的a扫描。利用健康人视网膜的物理和光学特性的参考值,我们使用蒙特卡罗方法和ONL模型来模拟每组的a扫描,并将其与真实OCT数据进行比较。这允许确定细胞特征的哪些改变是导致病变组OCT扫描中观察到的变化的原因。
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