Fully IC Label-Free Aptasensor with Interdigitated Microelectrodes in Microfluidic Channel

Abstract

So far, DNA microarrays are known as a surface on which sequences from thousands of different genes are covalently attached to fixed probes. By using DNA microarrays technology, it allows a parallel analysis for the selective nature of DNA-DNA or DNA-RNA hybridization, simultaneously. DNA microarrays require optically active labels attached to the target DNA and fluorescence sensing. Some pioneering Aptasensor are one type of DNA microarrays technology, which employs electrochemical labels, redox-active molecules or enzymes, which produces an electrical current through conductive electrodes in case of complementary sequences. DNA microarrays allow highly parallel and low cost analysis. In fact, they take advantage of the capability to fabricate a large number of miniaturized detection sites on a substrate to extract information after exposition to the target DNA to be detected or recognized.