Single ion channel CMOS electrochemical instrument for high throughput recording arrays

Haitao Li, Sina Parsnejad, A. Mason
{"title":"Single ion channel CMOS electrochemical instrument for high throughput recording arrays","authors":"Haitao Li, Sina Parsnejad, A. Mason","doi":"10.1109/MWSCAS.2015.7282111","DOIUrl":null,"url":null,"abstract":"This paper presents instrumentations for high throughput single ion channel recording array used for proteomics. The instrumentations incorporates two-stage amplifier using shared operational transconductance amplifier structure. The proposed sensor frontend reduces power consumption and area of circuit without any performance degradations in terms of bandwidth and noise. Two compact, low noise, low power circuits are introduced to address the proposed amplifier structure. As a results, over 400 ion channels are implemented on a single chip. Design #1 is suitable for recording ion currents as low as 20pA within 9kHz bandwidth using minimal power. Design #2 is able to sense input currents as low as 10pA within a maximum bandwidth of 100kHz.","PeriodicalId":216613,"journal":{"name":"2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MWSCAS.2015.7282111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9

Abstract

This paper presents instrumentations for high throughput single ion channel recording array used for proteomics. The instrumentations incorporates two-stage amplifier using shared operational transconductance amplifier structure. The proposed sensor frontend reduces power consumption and area of circuit without any performance degradations in terms of bandwidth and noise. Two compact, low noise, low power circuits are introduced to address the proposed amplifier structure. As a results, over 400 ion channels are implemented on a single chip. Design #1 is suitable for recording ion currents as low as 20pA within 9kHz bandwidth using minimal power. Design #2 is able to sense input currents as low as 10pA within a maximum bandwidth of 100kHz.
用于高通量记录阵列的单离子通道CMOS电化学仪器
本文介绍了用于蛋白质组学研究的高通量单离子通道记录阵列仪器。该仪器采用共享操作跨导放大器结构的两级放大器。所提出的传感器前端降低了功耗和电路面积,而在带宽和噪声方面没有任何性能下降。介绍了两种紧凑、低噪声、低功耗的电路来解决所提出的放大器结构。因此,在单个芯片上实现了400多个离子通道。设计#1适用于在9kHz带宽内使用最小功率记录低至20pA的离子电流。设计#2能够在100kHz的最大带宽内检测低至10pA的输入电流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信