Mechanically Stimulated Osteoblast Cells Growth

R. Aversa, A. Apicella, F. Tamburrino, F. Petrescu
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引用次数: 4

Abstract

The bones need to be built and then permanently restored to keep them functioning properly. Considering the multiple bone functions, their vitality is essential both to maintain the body and move it and to maintain its health and vigor. When most bones begin to age and have no vital function, the man also begins to age, lose water, minerals, electrolytes, energy, food. We can firmly affirm that healthy bones maintain an excellent health of the human body. All of the bones in the young have the role of deposit, water, electrolyte, minerals, energy, substances necessary for the growth and repair of human cells and organs, a part (red marrow) that permanently produces the vital blood for the organism with the three vital cell types: red (body oxygenation), white (which defends the body) and platelets (it clogs the blood when a wound appears). More recently, it is also known that the red marrow is responsible for the stem cells production, cells which are so necessary to the body because they can adapt to anywhere in the body in any organ, rapidly generating the various types of cells needed. In the bones of the young and most of the adult, all these functionalities appear, so that when an accident requires a human operation it is good to resort to mild and specialized interventions so that the bone in question can quickly recover all features. Otherwise, the body of that person has a major future health and integrity problem, as is the case with older people or those with serious bone diseases. The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating “scaffolds” to promote early regeneration in implanted bone healing phases. A biomimetic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces are finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer-aided simulations have been carried out. Such multidisciplinary approach allowed us to explore many novel ideas in modeling, design and fabrication of new nanostructured biomaterials and scaffolds with enhanced functionality and improved interaction with OB cells. In vivo tests of Titanium screw implanted in rabbit, tibiae have shown that mechanical stimulation was induced by the presence of bioactive hybrid perimplantar scaffold resulting in a differentiation and development of mesenchymal tissues. In order to investigate the relationship between bone growth and applied mechanical loading (strain), a piezoelectrically driven cantilever and a computer-controlled apparatus for “in vitro” tests has been developed and presented.
机械刺激成骨细胞生长
骨骼需要重建,然后永久修复,以保持其正常功能。考虑到骨骼的多种功能,它们的活力对于维持身体和运动以及保持身体的健康和活力至关重要。当大多数骨骼开始老化,失去重要功能时,人也开始衰老,失去水分、矿物质、电解质、能量和食物。我们可以坚定地肯定,健康的骨骼保持着人体的良好健康。年轻时所有的骨骼都有沉积物、水、电解质、矿物质、能量、人体细胞和器官生长和修复所必需的物质的作用,其中一部分(红骨髓)永久地为生物体生产重要的血液,其中有三种重要的细胞类型:红色(身体氧合)、白色(保护身体)和血小板(当伤口出现时堵塞血液)。最近,人们还知道,红骨髓负责干细胞的生产,这些细胞对人体非常必要,因为它们可以适应身体的任何地方和任何器官,迅速产生所需的各种类型的细胞。在年轻人和大多数成年人的骨骼中,所有这些功能都出现了,因此,当发生事故需要人工操作时,最好采取温和和专门的干预措施,以便有问题的骨骼能够迅速恢复所有功能。否则,这个人的身体就会有一个重大的未来健康和完整性问题,就像老年人或那些患有严重骨骼疾病的人一样。该研究开发并测试了新的混合仿生材料,作为机械刺激“支架”,促进植入骨愈合阶段的早期再生。提出了一种仿生纳米结构的骨传导材料包覆装置。使用自组装的混合有机-无机界面的混合网络的生物启发方法和模板生长最终确定,以扩展混合材料在医疗领域的使用。结合体内、体外和计算机辅助模拟进行。这种多学科的方法使我们能够在建模、设计和制造新的纳米结构生物材料和支架方面探索许多新颖的想法,这些材料和支架具有增强的功能和改善与OB细胞的相互作用。在兔胫骨植入钛螺钉的体内实验表明,生物活性杂交植入支架可诱导机械刺激,导致间充质组织分化和发育。为了研究骨生长与外加机械载荷(应变)之间的关系,开发并提出了一种压电驱动悬臂梁和计算机控制的“体外”试验装置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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