Efficient Fault Detection and Diagnosis of Digital Microfluidic Biochip Using Multiple Electrodes Actuation

Abstract

Nowadays, Digital Microfluidic biochip (DMFB) is a promising platform where we can concurrently execute complex bioassay operations. This automated, integrated chip is used in Many safety-critical applications like air-quality monitoring, point-of-care health assessment, automated drug discovery, parallel DNA analysis and this is possible only by deploying a robust testing mechanism. Some of the earlier reported testing and diagnosis algorithms are mostly concentrated on single fault localization or take a significant amount of time for multiple faults detection. Even in some cases, a non-faulty electrode incorrectly classified as a faulty electrode. Thus in this work, we have proposed a multiple electrodes actuation method for correct localization of the defective electrode(s) within very less time. Moreover, when some other bioassay operations are running in a biochip then also our proposed method can diagnose the faults of the biochip.