Angiogenesis In Oral Squamous Cell Carcinoma

A. Hande
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Abstract

Introducon : OSCC shows a high suscepbility for invasive growth and cervical lymph node metastasis. Prolonged exposure to carcinogens may lead to the unregulaon of tumor suppressor genes and oncogenes, epigenec and cytogenec alteraons, and mutaons in mitochondria. Angiogenesis is crical for tumor progression, as tumor cell growth frequently outstrips the supply of O and nutrients. Demonstraon of angiogenesis in tumor stroma can be 2 carried out by IHC using anbodies CD105. Thus, the present study aims at assessing the expression of CD105 in oral squamous cell carcinoma. Material and Methods : The study comprised of 60 histopathologically diagnosed and surgically operated cases of OSCC of various histopathological grades from the departmental archives. The paraffin embedded ssue secon of 4μm was obtained from archival ssues of OSCC (Group 1) and normal oral mucosa (Group 2) which were stained for roune Hematoxylin and Eosin and for the expression of CD 105 by immunohistochemistry for the determinaon of micro vessel density. Observaons & Results: We observed significantly increased MVD in poorly differenated OSCC in comparison to moderately differenated OSCC and well differenated OSCC. However, when comparison was made between the well and moderately differenated OSCC, the difference was stascally nonsignificant. Conclusion : There was an increased MVD, in poorly differenated OSCC, which could be used as an addional criterion to histologically grade the tumor.
口腔鳞状细胞癌中的血管生成
简介:OSCC表现出侵袭性生长和颈部淋巴结转移的高易感性。长期暴露于致癌物可能导致肿瘤抑制基因和癌基因的不调节、表观遗传和细胞遗传学的改变以及线粒体的突变。血管生成是肿瘤进展的关键,因为肿瘤细胞的生长经常超过O和营养的供应。利用抗体CD105进行免疫组化可以证明肿瘤基质中血管生成。因此,本研究旨在评估CD105在口腔鳞状细胞癌中的表达。材料和方法:本研究包括60例组织病理诊断和手术的不同组织病理分级的OSCC病例。取OSCC档案组织(1组)和正常口腔黏膜(2组)4μm的石蜡包埋组织,分别进行苏木精和伊红染色,免疫组化检测cd105表达,测定微血管密度。观察与结果:我们观察到,与中度分化和良好分化的OSCC相比,低分化OSCC的MVD显著增加。然而,当将轻度分化的OSCC与轻度分化的OSCC进行比较时,差异基本上不显著。结论:低分化OSCC中MVD升高,可作为肿瘤组织学分级的附加标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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