Prevalence and Associated Factors of Art Adverse Effect among PLWH on Art in Debre Markose Referal Hospital, North East Ethiopia, 2013

M. Asrat, Getachew Hailu, Molla Gedefaw, Mulugeta Tesfa
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引用次数: 3

Abstract

Antiretroviral treatments adverse effect is one of the challenges in HIV/AIDS prevention and control programs. The major objective of this study was assessment of the level of ART adverse effect and its associated factors among people living with HIV (PLWH) on ART in Debre Markos Referral Hospital from October 2 to November 30/2013. Institutional based cross-sectional quantitative type of study design was conducted to determine the level of ART adverse effect among randomly selected 373 adult PLWH on ART in Debre Markos referral hospital. The study participants were selected using systematic random sampling technique. Both primary and secondary data were gathered using a structured questionnaire. The collected data were entered, processed and analyzed in STATA V.11. The period prevalence of ART adverse effect was 51. 4%. The most common type of adverse effect was lipoathrophy (37.5%, n=72) and the least was Hepathotoxicity (0.52 %, n=1). The odds of ART adverse effect were 0. 523 times less likely among those who were literate compared to illiterate [AOR=0.477, 95% CI=0.28-0.812]. similarly, it was 0.44 times less likely among the study par-ticipants with preparatory school level of educational status compared to those with primary school [AOR=0.56, 95% CI=0.443-0.953]. The odds of ART adverse effect were 0.725 times less likely among those had a monthly income of ≥ 3551 Ethiopian Birr compared to those had no a regular monthly income [AOR=0.275,95%CI=0.098-0.773] and were 0.546 times less likely among substance non-abusers than abusers [AOR=0.454,95%CI=0.253-0.817]. The prevalence of ART adverse effect in Debre Markos referral Hospital was found. The leading adverse effect was Lipoathrophy. Factors such as educational status, income and substance abuse were identified independent determinants of ART adverse effect. The program managers, implementers and service providers need to take in to consideration the emerging need of adult education, health education and creation of income generating activities for adult PLWHs on ART in Debre Markos Referral Hospital. Furthermore it is better to disseminate information on the possible Antiretro-viral therapy adverse effects using leaflets and patient- physician regular education program.
2013年埃塞俄比亚东北部Debre Markose转诊医院艾滋病患者Art不良反应发生率及相关因素分析
抗逆转录病毒治疗的不良反应是艾滋病毒/艾滋病预防和控制项目面临的挑战之一。本研究的主要目的是评估2013年10月2日至11月30日在Debre Markos转诊医院接受抗逆转录病毒治疗的艾滋病毒感染者(PLWH)的抗逆转录病毒不良反应水平及其相关因素。采用基于机构的横断面定量型研究设计,以确定在Debre Markos转诊医院随机选择的373名接受抗逆转录病毒治疗的成年PLWH的不良反应水平。研究对象采用系统随机抽样方法进行选择。使用结构化问卷收集第一手和第二手数据。收集的数据在STATA V.11中输入、处理和分析。ART不良反应期患病率为51。4%。最常见的不良反应类型是脂肪萎缩(37.5%,n=72),最少的是肝毒性(0.52%,n=1)。ART不良反应发生率为0。受过教育的人患糖尿病的可能性是不识字的人的523倍[AOR=0.477, 95% CI=0.28-0.812]。同样,受教育程度为预科学校的研究参与者与受教育程度为小学的研究参与者相比,这种可能性低0.44倍[AOR=0.56, 95% CI=0.443-0.953]。月收入≥3551埃塞比尔的患者发生抗逆转录病毒药物不良反应的几率比无固定月收入的患者低0.725倍[比值比=0.275,95%CI=0.098-0.773],非药物滥用者发生抗逆转录病毒药物不良反应的几率比药物滥用者低0.546倍[比值比=0.454,95%CI=0.253-0.817]。调查了德布雷马科斯转诊医院抗逆转录病毒治疗不良反应的发生率。主要的不良反应是脂肪萎缩。教育状况、收入和药物滥用等因素被确定为ART不良反应的独立决定因素。方案管理人员、执行者和服务提供者需要考虑到在德布雷马科斯转诊医院为接受抗逆转录病毒治疗的成年艾滋病毒感染者开展成人教育、健康教育和创收活动的新需求。此外,最好使用传单和患者-医生定期教育计划来传播有关抗逆转录病毒治疗可能产生的不良反应的信息。
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