MALIGNANT NEOPLASMS OF FEMALE REPRODUCTIVE ORGANS IN DYNAMICS in 2011-2020, ON THE EXAMPLE OF NOVOKUZNETSK

Abstract

Significance. Malignant neoplasms are among the leading socially significant diseases. In recent years, the mortality rate from malignant neoplasms among females aged 16-54 in Russia has taken first place, slightly ahead of the traditional leader - mortality from diseases of the circulatory system. Therefore, early detection of oncopathology, including reproductive organs, means preservation of life, health and performance capability, and ultimately, the quality of female life, including young and middle-aged women. Purpose: to identify risk zones of oncopathology of female reproductive organs to ensure timely and adequate control actions and women's health improvement. Material and methods. The study was based on statistical reports of the Regional clinical oncology dispensary (Novokuznetsk branch) for 2011-2020. The reporting information has been translated into a database format (DB) with a 1-year observation unit. The database was created in the licensed statistical package IBM SPSS Statistics-19. The following methods of statistical analysis were used: calculation of median values of indicators, upper and lower quartiles; the Kendall’s Tau correlation method (Ʈ), the Mann-Whitney criterion (U). Results. The risk zones of oncopathology of the female population of Novokuznetsk as a whole and by age groups were identified. In terms of morbidity and mortality per 100 000 population, malignant neoplasms of the breast have the highest morbidity indicator, while ovarian cancer has the highest mortality rate during the year. At the same time, the highest detectability of stages III and IV of oncological diseases is in ovarian cancer. The risk zones of oncopathology by age are as follows: cervical cancer in females aged 40-44, breast cancer in females aged 60-64 and 65-69, and endometrial cancer and ovarian cancer in females aged 65-69. In these ages, the highest levels of the studied morbidity in the dynamics in 2011-2020 were revealed. Cervical cancer and breast cancer have a negative trend in crude incidence: a statistically significant growth of both absolute and relative (per 100 thousand population) indicators was revealed. As to ovarian cancer localization, there is a tendency towards a decreasing absolute indicator. Conclusions. The main study results can be used to conduct preventive examinations and medical examinations of women with a focus on identifying risk zones of the reproductive organ cancer by age group and localization. Thus, the results obtained contribute to adopting adequate and timely medical interventions and improvement of women's health.