The Effect of Platelet-Rich Fibrin on Bone Defects Repair in Experimental Animals: A Mini-Review

Abstract

Bone is a unique hard form of connective tissue as a result of its heavily calcified extra cellular components. Platelet-Rich Fibrin (PRF), a second generation platelet concentrate, becomes a powerful bioscaffold with an integrated reservoir of growth factors for tissue regeneration. Several studies showed that PRF has positive effect on soft and hard tissue regeneration. Here we present recent literature exploring the osteogenic effects of PRF alone or combined with other materials on bone defects healing in various animal models. period [5]. The growth factors present in PRF have been shown to promote fibroblast proliferation and accelerate bone repair. In addition, these factors increase tissue vascularity, the rate of collagen formation, and proliferation of mesenchymal stem cells, endothelial cells and osteoblasts. Several authors have also demonstrated that a fibrin matrix provides an optimal support for mesenchymal stem cells, which contribute to bone defects regeneration and of many other tissues [6].