THE ROLE OF CHLOROQUINE AND HYDROXYCHLOROQUINE IN PROPHYLAXIS OF COVID-19: A LITERATURE REVIEW

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions Pub Date : 2020-11-19 DOI:10.26911/the7thicph-FP.05.12

Dewi Indra Sari, M. Nadjib

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Abstract

ABSTRACT Background: A pandemic potential Covid-19 spread rapidly worldwide. Ministry of Health, Republic Indonesia recommended one of the Covid-19 treatments with combination of hydroxychloroquine/ chloroquine and azithromycin. However, the effectiveness and safety of antimalaria regime remain debating topic. This study aimed to investigate the role of chloroquine and hydroxychloroquine in prophylaxis of Covid-19. Subjects and Method: A systematic review was conducted by searching from PubMed, SpringerLink, and Cochrane Library databases. The keywords were “prophylaxis”, “chloroquine” OR “hydroxychloroquine” “SARS-CoV-2” OR “Covid-19”. The inclusion criteria were phase IIb clinical trials, double masking, comparative observational studies, open access articles published until August 2020. The exclusion criteria were inaccessible and duplicate articles. The quality of selected articles was critically appraised. The data were reported by PRISMA flow chart. Results: Three articles out of 117 articles met the criteria inclusion. The findings showed that hydroxychloroquine could not prevent Covid-19 compatible disease or confirmed infections when used as post-exposure prophylaxis. High dose chloroquine was not recommended for critically ill COVID-19 patients because of its potential side effects, especially when administered with azithromycin and oseltamivir. Covid-19 patients with the need for oxygenation were not suggested to use hydroxychloroquine. Conclusion: There is scarce evidence to support prophylaxis and treatment effects of chloroquine or hydroxychloroquine in COVID-19 patients. Further research on the safety and use of chloroquine or hydroxychloroquine is required in the management of Covid-19. Keywords: prophylaxis, Chloroquine, Hydroxychloroquine, SARS-CoV-2, Covid-19 Correspondence: Dewi Indra Sari. Masters Program in Public Health, Faculty of Public Health, Universitas Indonesia, Depok, West Java. Email: dindrasang@yahoo.com. Mobile: +628121983-6600. DOI: https://doi.org/10.26911/the7thicph.05.33

查看原文本刊更多论文

氯喹和羟氯喹在预防covid-19中的作用:文献综述

背景:一种具有大流行潜力的Covid-19在全球范围内迅速传播。印度尼西亚共和国卫生部推荐了羟氯喹/氯喹和阿奇霉素联合治疗Covid-19的一种方法。然而，抗疟方案的有效性和安全性仍然是有争议的话题。本研究旨在探讨氯喹和羟氯喹在新冠肺炎预防中的作用。研究对象和方法:通过检索PubMed、SpringerLink和Cochrane图书馆数据库进行系统评价。关键词为“预防”、“氯喹”或“羟氯喹”、“SARS-CoV-2”或“Covid-19”。纳入标准为IIb期临床试验、双掩蔽、比较观察性研究、2020年8月前发表的开放获取文章。排除标准为不可访问和重复的文章。所选文章的质量得到了严格的评价。数据采用PRISMA流程图报告。结果:117篇文章中有3篇符合纳入标准。研究结果表明，羟氯喹不能预防Covid-19相容疾病或确诊感染，当用作暴露后预防时。由于潜在的副作用，不建议对COVID-19危重患者使用大剂量氯喹，特别是与阿奇霉素和奥司他韦同时使用时。需要氧合的Covid-19患者不建议使用羟氯喹。结论:目前尚缺乏证据支持氯喹或羟氯喹对COVID-19患者的预防和治疗效果。在Covid-19的管理中，需要进一步研究氯喹或羟氯喹的安全性和使用。关键词:预防，氯喹，羟氯喹，SARS-CoV-2, Covid-19公共卫生硕士课程，公共卫生学院，印度尼西亚大学，德波，西爪哇。电子邮件:dindrasang@yahoo.com。手机:+ 628121983 - 6600。DOI: https://doi.org/10.26911/the7thicph.05.33

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Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions

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