Low Gastric Bicarbonate Secretions Seen in Cigarette Smokers

Abstract

Summary Sucralfate drug is well known for its miraculous effects on gastroduodenal mucosa and its therapeutic effects on peptic ulcer, but its mechanism of action is still a mystery. This drug administration of 3g daily for 4-6 weeks is an effective treatment on gastric bicarbonate secretion. Our observational study was focused on gastric bicarbonate secretion in 14 healthy smokers and 11 healthy age and sex-matched non-smoker volunteers. The outcome of the study suggested that smokers produced low gastric bicarbonate secretions compared to non-smokers.