[Late effect of carbon disulfide on the lymph nodes in rats].

Abstract

Cell composition of the cortical plateau, medullary cords and lymphoid nodules++ has been determined in 180 Wistar rats in 2 weeks, 1 and 3 months after inhalation of carbon disulfate vapour for 2, 7 and 14 days in a maximum permissible concentration (1 mg/m3) and in the control group. In 2 weeks after cessation of the vapour inhalation activity of lymphocytopoiesis, blastopoiesis, cell differentiation decreases, macrophagal and plasmocytic reactions are weakly manifested. In 1 month certain signs of compensatory-adaptive reaction are noted; they are seen as increasing proliferative processes and activation of cell differentiation in the lymphoid nodules++ and a sharp plasmatization of the medullary cords. In 3 months after the experiment retardation of lymphocytopoiesis is still definitely manifested in the cortical plateau and medullary cords and essential destructive processes are observed against the background of local increase of the functional activity of the lymphoid nodules++.