Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides

Claude Hélène
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引用次数: 114

Abstract

Synthetic oligonucleotides can be used to control the expression of specific genes. When targeted to messenger RNAs, oligonucleotides inhibit translation (the antisense strategy). Oligonucleotides can also be targeted to specific sequences of the DNA double helix where they inhibit transcription (the antigene strategy). Both strategies can be applied to control the expression of oncogenes in tumour cells. The mRNAs of several oncogenes have been chosen as targets for antisense oligonucleotides (myc, myb, bc12, abl, ras…). Discrimination between the proto-oncogene and the oncogene can be achieved in the case of ras oncogenes where activation results from point mutations in the coding sequence. Regulatory sequences involved in controlling the transcription of oncogenes can also be used as targets for antigene oligonucleotides (myc, ras).

基于反义和抗原寡核苷酸的序列特异性癌基因抑制剂的合理设计
合成的寡核苷酸可用于控制特定基因的表达。当靶向信使rna时,寡核苷酸抑制翻译(反义策略)。寡核苷酸也可以靶向DNA双螺旋的特定序列,在那里它们抑制转录(抗原策略)。这两种策略都可以用于控制肿瘤细胞中癌基因的表达。一些癌基因的mrna已被选择作为反义寡核苷酸(myc, myb, bc12, abl, ras…)的靶标。在ras癌基因的情况下,原癌基因和癌基因之间的区分可以实现,ras癌基因的激活是由编码序列中的点突变引起的。参与控制癌基因转录的调控序列也可以作为抗原寡核苷酸(myc, ras)的靶标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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