Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone

William N. Scott, Peter Mullen, William R. Miller
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引用次数: 8

Abstract

To clarify the mechanism by which the luteinising hormone-releasing hormone agonist, buserelin, may have direct effects on breast cancer cells, factors potentially influencing its action have been studied in the MCF-7 breast cancer cell line. Oestradiol and epidermal growth factor (EGF), which stimulate the growth of MCF-7 cells in culture, reversed, at least in part, the inhibitory effects of buserelin. Insulin also abolished growth inhibition. Quantitative effects of buserelin differed according to the batch of fetal calf serum used as media supplement. These data suggest that the direct inhibitory effects of buserelin on breast cancer cells are mediated at least in part by an antagonism of growth-promoting factors.

影响MCF-7细胞对黄体生成素释放激素激动剂反应的因素
为了阐明促黄体激素释放激素激动剂buserelin可能对乳腺癌细胞产生直接作用的机制,在MCF-7乳腺癌细胞系中研究了可能影响其作用的因素。雌二醇和表皮生长因子(EGF)刺激MCF-7细胞在培养中生长,至少部分地逆转了buserelin的抑制作用。胰岛素也消除了生长抑制。胎牛血清培养基添加量不同,布瑟林的定量效果也不同。这些数据表明,buserelin对乳腺癌细胞的直接抑制作用至少部分是由生长促进因子的拮抗介导的。
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