A Review on the Immunological Techniques Use for Detection of Schistosoma spp Infection

Abstract

Over 200 million people are suffering from the debilitating schistosomiasis, which has the greatest morbidity and mortality rates in African nations. Schistosomiasis continues to be a tropical disease that receives little attention from governments and healthcare Institutions while having a wide range of negative impacts on society's health and socioeconomic hardship. The establishment of precise investigation for both gut and urinary schistosomiasis is one of the crucial areas that are severely undeveloped. A review was conducted to highlight immunological methods used to detect Schistosomiasis. Databases from ScienceDirect, World Health Organization, and PubMed were used. Articles for which at least the abstract was available in English were selected for the present study. Relevant articles were screened, duplicates were eliminated, eligibility standards were followed, and qualified studies were reviewed. Techniques including Skin Reaction Test/Biopsy, Indirect Immuno-Fluorescence Test (IFT), Indirect Hemagglutination Test (IHAT), Circumoval Precipitin Test (Copt), Monoclonal Antibodies Test (Mabt), ELISA, and others were discussed. The challenges faced by these techniques were also highlighted. Among the techniques discussed, ELISA was found to be the most widely used as it is the most effective, easy to use, and could detect both chronic and acute Schistosomiasis