{"title":"Systemically applied luteinizing hormone-releasing hormone (LHRH) reduces behavioural activity in rats and increases sleep activity.","authors":"R Arnold, F Klingberg, W Schäker","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Groups of each 8 male Long-Evans rats were treated with 1 or 10 micrograms/kg LHRH intraperitoneally and compared with control rats which received the vehicle fluid (NaCl-solution). Ambulatory activity in an open field (OF), entrance to central fields and the mobility index were significantly decreased by both doses. Correspondingly, wheel running and movement velocity were significantly decreased. A further group of 8 rats with chronically implanted electrodes which was habituated to sessions showed an increase of slow-wave sleep and a significant reduction of waking and active states with maximal expression 45 min after ip application of 10 micrograms/kg LHRH. Paradoxical sleep was slightly reduced. Sleep-wakefulness cyclograms showed increase of a sleep phase duration to 175% and of single slow wave sleep phase duration to 140% after LHRH. Phases of drowsiness were also prolonged.</p>","PeriodicalId":8948,"journal":{"name":"Biomedica biochimica acta","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedica biochimica acta","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Groups of each 8 male Long-Evans rats were treated with 1 or 10 micrograms/kg LHRH intraperitoneally and compared with control rats which received the vehicle fluid (NaCl-solution). Ambulatory activity in an open field (OF), entrance to central fields and the mobility index were significantly decreased by both doses. Correspondingly, wheel running and movement velocity were significantly decreased. A further group of 8 rats with chronically implanted electrodes which was habituated to sessions showed an increase of slow-wave sleep and a significant reduction of waking and active states with maximal expression 45 min after ip application of 10 micrograms/kg LHRH. Paradoxical sleep was slightly reduced. Sleep-wakefulness cyclograms showed increase of a sleep phase duration to 175% and of single slow wave sleep phase duration to 140% after LHRH. Phases of drowsiness were also prolonged.
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