Disturbance of thyroidal iodine metabolism in BB/W rat.

Endocrinologia japonica Pub Date : 1991-12-01 DOI:10.1507/endocrj1954.38.647

S Miura, Y Hara, M Iitaka, N Fukasawa, K Hase, M Urabe, Y Sakatsume, M Yanagisawa, J Ishii, S Kawazu

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引用次数: 4

Abstract

To investigate the thyroid function in Bio-Breeding Worcester (BB/W) rats, we have examined the iodine metabolism, serum TSH and thyroid hormone levels in 8- and 16-week-old BB/W and normal Wistar (W) rats. At 8 weeks of age, serum TSH levels were significantly higher in BB/W rats than in W rats, although there was no difference in the serum levels of free T3 and free T4. Furthermore, the thyroidal radioactive iodine incorporation at 48 h was significantly lower in BB/W rats, suggesting that they might have some defects in iodine organification. At 16 weeks of age, serum TSH levels were also significantly higher in BB/W rats than in W rats. Furthermore, serum TSH levels in 16-week-old BB/W rats were significantly higher than in 8-week-old BB/W rats. The thyroid weight was significantly greater in BB/W rats, probably due to the increased serum TSH. The thyroidal radioactive iodine uptake at 48 h and the iodine content in the thyroid homogenates were significantly lower in BB/W rats. These results suggest that BB/W rats have some defect in iodine metabolism resulting in impaired thyroid hormone synthesis.

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BB/W大鼠甲状腺碘代谢紊乱。

为了研究生物育种伍斯特(BB/W)大鼠的甲状腺功能，我们检测了8、16周龄BB/W和正常Wistar (W)大鼠的碘代谢、血清TSH和甲状腺激素水平。8周龄时，BB/W大鼠血清TSH水平显著高于W大鼠，但血清游离T3和游离T4水平无显著差异。此外，BB/W大鼠48 h甲状腺放射性碘掺入量明显降低，提示BB/W大鼠可能在碘组织方面存在缺陷。16周龄时，BB/W大鼠血清TSH水平也显著高于W大鼠。16周龄BB/W大鼠血清TSH水平显著高于8周龄BB/W大鼠。BB/W大鼠甲状腺重量明显增加，可能是由于血清TSH升高。BB/W大鼠48 h甲状腺放射性碘摄取和甲状腺匀浆中碘含量显著降低。提示BB/W大鼠碘代谢存在一定缺陷，导致甲状腺激素合成受损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Endocrinologia japonica

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