D. Cavalla
{"title":"Chapter 15. Future Perspectives in Drug Repurposing","authors":"D. Cavalla","doi":"10.1039/9781839163401-00301","DOIUrl":null,"url":null,"abstract":"Drug repurposing offers a more efficient route to medicinal innovation than conventional new molecular entity research, and proposals for repurposing projects can come from in silico algorithms, pharmacological experimentation, clinical serendipity or retrospective analysis of human data. These approaches offer a much larger number of hypotheses for validation than can be resourced, and rigorous multidisciplinary prioritisation is required. The recent COVID-19 pandemic has highlighted the potential for the approach, which has produced three clinically effective treatments in under a year, including two regulatory approvals for emergency use, and one drug with demonstrated efficacy against mortality. Challenges remain in how to provide additional commercial incentives for drug companies to support late-stage development of repurposing projects and fully realise its healthcare potential. © The Royal Society of Chemistry 2022.","PeriodicalId":202024,"journal":{"name":"Drug Repurposing","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Repurposing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781839163401-00301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
第15章。药物再利用的未来展望
与传统的新分子实体研究相比,药物再利用为药物创新提供了更有效的途径,重新利用项目的建议可以来自计算机算法、药理学实验、临床偶然发现或对人类数据的回顾性分析。这些方法为验证提供了大量的假设,而不是资源,并且需要严格的多学科优先排序。最近的COVID-19大流行凸显了该方法的潜力,该方法在不到一年的时间里产生了三种临床有效的治疗方法,包括两种紧急使用的监管批准,以及一种已被证明具有降低死亡率功效的药物。挑战仍然是如何为制药公司提供额外的商业激励,以支持重新利用项目的后期开发,并充分发挥其保健潜力。©英国皇家化学学会2022。
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