A Hänsicke, E Krause, M Bienert, M Schmidt, S Kobert, V Schellenberger, H D Jakubke, K D Kaufmann
{"title":"Chymotrypsin-catalyzed fragment coupling synthesis of GnRH-analogs.","authors":"A Hänsicke, E Krause, M Bienert, M Schmidt, S Kobert, V Schellenberger, H D Jakubke, K D Kaufmann","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.</p>","PeriodicalId":8948,"journal":{"name":"Biomedica biochimica acta","volume":"50 10-11","pages":"S201-4"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedica biochimica acta","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
D-Xaa6-GnRH analogs (Xaa: Ala, Nal1), Phe, Ser(tBu), Trp) were prepared by chymotrypsin catalyzed 3 + 7 fragment coupling synthesis with conversion rates of the amino component in the range from 90.3 to 97.4%. For D-Phe6-GnRH the method was scaled up to production level.
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