The Relationship Between the Arterial Geometry and Wall Shear Stress in the Vertebrobasilar System

Fangjia Pan, H. Anzai, S. Mugikura, Ko Kitamura, M. Ohta
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引用次数: 0

Abstract

Vertebrobasilar atherosclerosis is an arterial disease; without successful treatment, it has a mortality rate approximately 80%–95%. Thus, predicting risk factors of vertebrobasilar atherosclerosis is of utmost importance. Previous studies have demonstrated that wall shear stress (WSS) contributes to atherosclerosis. In addition, geometry and WSS are correlated. The present study focuses on the description of equation using detailed relationship between arterial geometry and WSS in the vertebrobasilar system (VBS); magnetic resonance (MR) imaging with computational fluid dynamics (CFD) was used for the analysis. Using constructed patient-specific models, WSS of basilar arteries (BAs) was calculated and then analyzed with morphological parameters. According to the statistical results, both the area and curvature of BAs are associated with WSS. Based on the relations, a liner fitted equation can be proposed. As this study is underway, more precise evaluation of the correlation between morphology and fluid shear stress could help predict risk factors and select treatment methods for this arterial disease.
椎基底动脉系统动脉几何形态与管壁剪切应力的关系
椎基底动脉粥样硬化是一种动脉疾病;如果治疗不成功,其死亡率约为80%-95%。因此,预测椎基底动脉粥样硬化的危险因素至关重要。先前的研究表明,壁面剪切应力(WSS)有助于动脉粥样硬化。此外,几何形状与WSS相关。本研究的重点是利用椎基底动脉系统(VBS)动脉几何形状与WSS之间的详细关系来描述方程;采用计算流体力学(CFD)的磁共振成像(MR)进行分析。利用构建的患者特异性模型,计算基底动脉(BAs) WSS,并结合形态学参数进行分析。根据统计结果,ba的面积和曲率都与WSS有关。基于这些关系,可以提出线性拟合方程。随着这项研究的进行,更精确地评估形态学和流体剪切应力之间的相关性可以帮助预测这种动脉疾病的危险因素和选择治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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