[An informational approach to recognizing the similarity of tRNA genes and their global classification].

Abstract

Based on informational approach to the comparative analysis of DNA sequences and the conception of fuzzy relations, new classification schemes were suggested for two aggregates of tRNA genes from the EMBL-8 data bank connecting amino acids TRP and ASP. These classification schemes are presented as a dendrogram and reflect possible evolutionary interrelation between tRNA genes in both aggregates. Evolutionary interrelations between tRNA genes were analyzed from two standpoints: 1) taking into consideration the interrelation between DNA sequences by all four nucleotides; 2) taking into account possible evolutionary pressure to the divergence of DNA sequences towards transitions. The similarity and difference of dendrograms for each gene aggregate were considered in both instances. It was shown that the analysis of all possible directions of the evolutionary pressure to the divergence of DNA and RNA sequences provides a new approach to the construction of a global tRNA phylogeny.