ANTIOXIDANT ACTIVITY, SKIN IRRITAION POTENTIAL AND CHEMICAL COMPOSITION OF CLOVE LEAF OIL FROM WEST JAVA INDONESIA

Jurnal Sains Materi Indonesia Pub Date : 2021-11-01 DOI:10.17146/jsmi.2021.23.1.6398

Dwinna Rahmi, R. Yunilawati, I. Setiawati, Irwinanita Irwinanita, B. N. Jati, A. Riyanto, Yemirta Yemirta, N. N. Aidha

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Abstract

ANTIOXIDANT ACTIVITY, SKIN IRRITATON POTENTIAL, AND CHEMICAL COMPOSITION OF CLOVE LEAF OIL FROM WEST JAVA INDONESIA. Essential oils with specific chemical compositions have the potential as a source of antioxidants in cosmetics, however, in general, essential oils are not safe because of the potential for skin irritation. This study aims is to perform fractionation to obtain clove oil with a chemical composition that is safe on the skin and does not reduce its antioxidant activity. Fractionation was performed at a temperature of 100 – 285 oC. Chemical composition was determined by Mass Chromatography Spectrometry (GC-MS), antioxidant activity by DPPH method, and irritation potential by in-vivo patch test. The results showed chemical components of clove oil were eugenol, copaene, beta caryophyllene, iso-eugenol, alpha caryophyllene, cadinene, caryophyllene oxide, caryophylla and beta caryophylla. Fractions with chemical compositions of eugenol and beta caryophyllene as the main components and copaene, iso-eugenol, alpha caryophyllene, cadinene as secondary components have very light erythema and no potential irritation to the skin. The fraction produced from the fractionation of crude clove oil at a temperature of 235 – 260 oC has the highest antioxidant activity of 10.17 mg/L.

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印度尼西亚西爪哇丁香叶油的抗氧化活性、皮肤刺激电位和化学成分

印度尼西亚西爪哇丁香叶油的抗氧化活性、皮肤刺激电位和化学成分。含有特定化学成分的精油有可能成为化妆品中抗氧化剂的来源，然而，一般来说，精油是不安全的，因为它有可能刺激皮肤。这项研究的目的是通过分离得到丁香油，其化学成分对皮肤是安全的，并且不会降低其抗氧化活性。分馏温度为100 ~ 285℃。采用质谱联用(GC-MS)法测定化学成分，DPPH法测定抗氧化活性，体内贴片试验测定刺激电位。结果表明，丁香油的化学成分主要为丁香酚、丁香烯、丁香烯、异丁香酚、丁香烯、丁香烯、丁香烯、丁香烯氧化物、丁香烯和丁香烯。以丁香酚和-石竹烯为主要化学成分，以copaene、异丁香酚、-石竹烯、cadinene为次要化学成分的馏分，其红斑非常轻，对皮肤没有潜在的刺激性。在235 ~ 260℃条件下对丁香粗油进行分馏，其抗氧化活性最高，为10.17 mg/L。

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Jurnal Sains Materi Indonesia

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