Hairy cell leukaemia: The role of alpha interferon

Leonidas C. Platanias , Mark J. Ratain
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引用次数: 7

Abstract

Hairy cell leukaemia (HCL) is a chronic progressive disease of predominantly middle-aged men. Alpha interferon has been shown to induce significant responses in HCL patients. With interferon treatment the platelet count normalizes first, followed by the haemoglobin and neutrophil counts. The number of hairy cells in the bone marrow decreases and granulocytic, erythroid and megakaryocytic cells increase. Interferon is well tolerated with the most common side effect being a flu-like syndrome. A number of HCL patients will develop neutralizing antibodies and in these cases the chemotherapeutic agents pentostatin and 2-chlorodeoxyadenosine should be considered. Preliminary results with these agents are promising and further trials are ongoing to confirm their clinical promise.

毛细胞白血病:干扰素的作用
毛细胞白血病(HCL)是一种慢性进行性疾病,主要发生于中年男性。α干扰素已被证明能在HCL患者中引起显著的反应。干扰素治疗后,血小板计数首先恢复正常,其次是血红蛋白和中性粒细胞计数。骨髓中毛细胞数量减少,粒细胞、红细胞和巨核细胞增多。干扰素耐受性良好,最常见的副作用是流感样综合征。许多HCL患者会产生中和抗体,在这些情况下,化疗药物戊他汀和2-氯脱氧腺苷应该考虑。这些药物的初步结果是有希望的,进一步的试验正在进行中以确认它们的临床前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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