Efficacy of Locally Delivered Bifidobacterium Probiotic Gel as an Adjunctive Therapy in Periodontitis Patients (Clinical and Microbiological Study)

Dina R. Abuazab, U. El-Shinnawi, M. El-daker
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Abstract

Objectives: This study evaluates the clinical and microbiological effect of Bifidobacterium probiotic gel as an adjunctive therapy to scaling and root planning (SRP) in chronic periodontitis patients and compering this effect with Chlorhexidine gel. Materials and Methods: Thirty chronic periodontitis patients (18 females, 12 males, aged between 30 and 50 years) were involved in the study. They were classified into 3 groups randomly. 1 group composed of 10 patients who received SRP associated with the subgingival application of Bifidobacterium probiotic gel, 2 group composed of 10 patients who received SRP associated with the subgingival application of Chlorhexidine gel and 3 group composed of 10 patients who received SRP only. Local drug delivery was applied once weekly for six weeks. All patients were evaluated clinically by measuring periodontal parameters (Plaque Index, Gingival Index, Probing Pocket Depth and Clinical Attachment Level) , and microbiologically by culturing plaque samples anaerobically for detection of total bacterial count, p.gingivalis & p.intermedia counts at baseline and six weeks after periodontal treatment. Results: All periodontal parameters (PI, GI, PPD and CAL), total bacterial count in addition to p.gingivalis & p.intermedia counts were reduced significantly after six weeks among all the groups. However by comparing in between groups there was significant difference in p.gingivalis & p.intermedia counts between groups 1&3 also between groups 2& 3. Conclusion: The local application of Bifidobacterium probiotic gel offers a promising therapeutic approach in periodontal treatment as adjunct to SRP.
局部给予双歧杆菌益生菌凝胶辅助治疗牙周炎的疗效(临床与微生物学研究)
目的:评价双歧杆菌益生菌凝胶辅助治疗慢性牙周炎患者的临床和微生物学效果,并与氯己定凝胶进行比较。材料与方法:30例慢性牙周炎患者,其中女性18例,男性12例,年龄30 ~ 50岁。随机分为3组。1组10例合并双歧杆菌益生菌凝胶龈下应用SRP, 2组10例合并洗必定凝胶龈下应用SRP, 3组10例单纯应用SRP。局部给药每周一次,连续6周。所有患者通过测量牙周参数(菌斑指数、牙龈指数、探测袋深度和临床附着水平)进行临床评估,并在牙周治疗基线和治疗后6周通过厌氧培养菌斑样本检测细菌总数、牙龈卟啉菌和中间卟啉菌计数。结果:治疗6周后,各组患者牙周指标(PI、GI、PPD、CAL)、细菌总数、牙龈假体及中间假体计数均显著降低。但组间比较,1、3组间、2、3组间牙龈假单胞菌及中间假单胞菌计数差异均有统计学意义。结论:局部应用双歧杆菌益生菌凝胶作为牙周治疗的辅助药物,是一种很有前景的治疗方法。
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