Gelatinous transformation of the bone marrow in anorexia nervosa: Report of two cases.

Abstract

Gelatinous transformation of the bone marrow was observed in two cases of anorexia nervosa. Electron microscopic observation revealed an amorphous substance in the intercellular spaces and histochemical analysis identified it to be acid mucopolysaccharide. Blue-green granules in marrow hitiocytes were observed in one case. Acanthocytosis was observed in both cases. These marrow and blood changes were rapidly normalized after the nutritional improvement in both cases.