[The possible effect of amino acids forming a loop in the surface layer of subunits on the electrophoretic mobility of enzymes in the alcohol/polyol dehydrogenase family].

V E Sudovtsov
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Abstract

Relative electrophoretic mobility (REM) of alcohol dehydrogenases from equine hepatocyte cytoplasm was low probably due to the presence of a loop which consisted of 21 amino acid residues in the surface layer of the enzyme subunits. The REM of multiple molecular forms of alcohol dehydrogenases from yeast cell cytoplasm was higher as consistent with the absence of this loop in the surface layer of the enzyme subunits. Possible role of amino acid residues comprising the loop, in the formation of total charge and their effect on REM values of enzymes from the alcohol/polyol dehydrogenase family are discussed.

[氨基酸在亚基的表层形成一个环对醇/多元醇脱氢酶家族中酶的电泳迁移率的可能影响]。
马肝细胞质乙醇脱氢酶的相对电泳迁移率(REM)较低,可能是由于在酶亚基的表层存在一个由21个氨基酸残基组成的环。酵母细胞质中多种分子形式的乙醇脱氢酶的REM较高,这与酶亚基的表面层中不存在该环相一致。讨论了构成环的氨基酸残基在总电荷形成中的可能作用及其对醇/多元醇脱氢酶家族酶的REM值的影响。
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