Formulation and evaluation of microsphere of glipizide

Abstract

The present study aims to carried out to prepare and evaluate the floating microsphere Glipizide using  Eudragit RS 100 in a combination with Polyethylene Oxide in various proportions. The following experimental protocol was therefore designed to allow a systemic approach to the study and we concludes that Drug absorption in the GIT is a highly variable process, prolonging gastric retention of the dosage forms and extends the time of drug absorption. Floating hollow microspheres are prepared with enteric coated polymer (Eudragit RS 100) successfully by the solvent evaporation technique. Upon incorporation of the hydrophilic polymer such as polyethylene oxide in the shell of microballoons, the amount of drug released from microspheres could be enhanced.