Mitoxantrone in malignant pleural mesothelioma: A study by the EORTC lung cancer cooperative group

Abstract

46 patients with malignant pleural mesothelioma were entered in a phase II study of mitoxantrone 14 mg/m² every 3 weeks. Histology was confirmed by a pathology panel. None of the patients had received previous chemotherapy. Toxicity was mainly mild gastrointestinal and haematological side-effects. Out of 34 patients evaluated for response, only 1 partial response was recorded. Mitoxantrone at this dose and schedule has marginal activity in malignant mesothelioma.